The German Uranium Miners’ Biobank—A Biobank for OMICs Radiation Research
نویسندگان
چکیده
Systematic bio- and databanks are key prerequisites for modern radiation research to investigate response mechanisms in the context of genetic, environmental lifestyle-associated factors. This report presents current status German Uranium Miners’ Biobank. In 2008, databank was established at Federal Office Radiation Protection, sampling biological materials from former uranium miners with without lung cancer initiated. For this purpose, various specimens, such as DNA RNA, were isolated blood samples well formalin-fixed paraffin-embedded tissue. High-quality biomaterials suitable OMICs associated data on occupational dust exposure, medical lifestyle over 1000 individuals have been stored so far. Various experimental data, e.g., genome-wide SNPs, whole genome transcriptomic miRNA individual chromosomal aberration subgroups biobank samples, already available upon request in-depth radiation-induced long-term effects, susceptibility radon-induced fingerprints cancer. is first systematic miners´ worldwide that radiation-exposed workers. It offers opportunity link perturbations pathways or processes putative adverse outcome(s) by profiling different organization levels.
منابع مشابه
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ژورنال
عنوان ژورنال: Radiation
سال: 2022
ISSN: ['2673-592X']
DOI: https://doi.org/10.3390/radiation2010005